Recoverin and Ca2+ in vertebrate phototransduction
Identifieur interne : 000C73 ( Main/Exploration ); précédent : 000C72; suivant : 000C74Recoverin and Ca2+ in vertebrate phototransduction
Auteurs : James B. Hurley [États-Unis]Source :
- Behavioral and Brain Sciences [ 0140-525X ] ; 1995-09.
Abstract
Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin with photoreceptor membranes.
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DOI: 10.1017/S0140525X00039182
Affiliations:
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